Genome-wide association study of lung function and clinical implication in heavy smokers

Genome-wide association study of lung function and clinical implication in heavy smokers

Abstract Background The aim of this study is to identify genetic loci associated with post-bronchodilator FEV1/FVC and FEV1, and develop a multi-gene predictive model for lung function in COPD. Methods Genome-wide association study (GWAS) of post-bronchodilator FEV1/FVC and FEV1 was performed in 164...

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Bibliographic Details
Main Authors: Xingnan Li, Victor E. Ortega, Elizabeth J. Ampleford, R. Graham Barr, Stephanie A. Christenson, Christopher B. Cooper, David Couper, Mark T. Dransfield, Mei Lan K. Han, Nadia N. Hansel, Eric A. Hoffman, Richard E. Kanner, Eric C. Kleerup, Fernando J. Martinez, Robert Paine, Prescott G. Woodruff, Gregory A. Hawkins, Eugene R. Bleecker, Deborah A. Meyers, for the SPIROMICS Research Group
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Medical Genetics
Subjects:
COPD
GWAS
Lung function
rs28929474
SERPINA1
SPIROMICS
Online Access:http://link.springer.com/article/10.1186/s12881-018-0656-z

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http://link.springer.com/article/10.1186/s12881-018-0656-z

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