Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer

Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer

Abstract Most lung cancer patients with metastatic cancer eventually relapse with drug-resistant disease following treatment and EGFR mutant lung cancer is no exception. Genome-wide CRISPR screens, to either knock out or overexpress all protein-coding genes in cancer cell lines, revealed the landsca...

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Bibliographic Details
Main Authors: Matthias Pfeifer, Jonathan S. Brammeld, Stacey Price, James Pilling, Deepa Bhavsar, Anca Farcas, Jessica Bateson, Anjana Sundarrajan, Ricardo J. Miragaia, Nin Guan, Stephanie Arnold, Laiba Tariq, Michael Grondine, Sarah Talbot, Maria Lisa Guerriero, Daniel J. O’Neill, Jamie Young, Carlos Company, Shanade Dunn, Hannah Thorpe, Matthew J. Martin, Kimberly Maratea, Daniel Barrell, Miika Ahdesmaki, Jerome T. Mettetal, Functional Genomics Centre, James Brownell, Ultan McDermott
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06190-w

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https://doi.org/10.1038/s42003-024-06190-w

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