Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating Jmjd3

Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating Jmjd3

Statins are known to be anti-inflammatory, but the mechanism remains poorly understood. Here, we show that macrophages, either treated with statin in vitro or from statin-treated mice, have reduced cholesterol levels and higher expression of Jmjd3, a H3K27me3 demethylase. We provide evidence that lo...

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Bibliographic Details
Main Authors: Zeina Salloum, Kristin Dauner, Yun-feng Li, Neha Verma, David Valdivieso-González, Víctor Almendro-Vedia, John D Zhang, Kiran Nakka, Mei Xi Chen, Jeffrey McDonald, Chase D Corley, Alexander Sorisky, Bao-Liang Song, Iván López-Montero, Jie Luo, Jeffrey F Dilworth, Xiaohui Zha
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
cholesterol
macrophages
inflammation
Online Access:https://elifesciences.org/articles/85964

Internet

https://elifesciences.org/articles/85964

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