Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice

Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice

Abstract Background and aims Kinin B1 receptors (B1Rs) are implicated in the pathogenesis of fibrosis. This study examined the anti-fibrotic effects of B1R blockade with BI 113823 in two established mouse models of hepatic fibrosis induced by intraperitoneal carbon tetrachloride (CCl4) injection or...

Full description

Bibliographic Details
Main Authors: Dileep Reddy Rampa, Huiying Feng, Sivakumar Allur-Subramaniyan, Kwanseob Shim, Anton Pekcec, Dongwon Lee, Henri Doods, Dongmei Wu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
B1R
BI 113823
Hepatic inflammation
Hepatic fibrosis
Portal hypertension
PI3K/AKT signalling pathway
Online Access:https://doi.org/10.1186/s12967-022-03808-7

Internet

https://doi.org/10.1186/s12967-022-03808-7

Similar Items