Loss of prolyl carboxypeptidase in two-kidney, one-clip goldblatt hypertensive mice.

It is well documented that angiotensin (Ang) II contributes to kidney disease progression. The protease prolyl carboxypeptidase (PRCP) is highly expressed in the kidney and may be renoprotective by degrading Ang II to Ang-(1-7). The aim of the study was to investigate whether renal PRCP protein expr...

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Bibliographic Details
Main Authors: Nadja Grobe, Orly Leiva, Mariana Morris, Khalid M Elased
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0117899