Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase

Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase

HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesylated and geranylgeranylated proteins. Here, we in...

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Bibliographic Details
Main Authors: Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel H. Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Lipid Research
Subjects:
cholesterol synthesis and regulation
liver
endoplasmic reticulum
animal models
3-hydroxy-3-methylglutaryl-coenzyme A
adeno-associated virus
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752060027X

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http://www.sciencedirect.com/science/article/pii/S002222752060027X

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