Ritanserin suppresses acute myeloid leukemia by inhibiting DGKα to downregulate phospholipase D and the Jak-Stat/MAPK pathway

Ritanserin suppresses acute myeloid leukemia by inhibiting DGKα to downregulate phospholipase D and the Jak-Stat/MAPK pathway

Abstract Refractory or relapsed (R/R) AML is the most challenging form of AML to treat. Due to frequent genetic mutations, therapy alternatives are limited. Here, we identified the role of ritanserin and its target DGKα in AML. Several AML cell lines and primary patient cells were treated with ritan...

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Bibliographic Details
Main Authors: Jinshui Tan, Mengya Zhong, Yanyan Hu, Guangchao Pan, Jingwei Yao, Yuanfang Tang, Hongpeng Duan, Yuelong Jiang, Weihang Shan, Jiaqi Lin, Yating Liu, Jiewen Huang, Huijian Zheng, Yong Zhou, Guo Fu, Zhifeng Li, Bing Xu, Jie Zha
Format: Article
Language:English
Published: Springer 2023-07-01
Series:Discover Oncology
Subjects:
Ritanserin
R/R AML
DGKα
Jak-Stat
MAPK
Online Access:https://doi.org/10.1007/s12672-023-00737-9

Internet

https://doi.org/10.1007/s12672-023-00737-9

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