A synonymous mutation in IGF-1 impacts the transcription and translation process of gene expression

A synonymous mutation in IGF-1 impacts the transcription and translation process of gene expression

Insulin-like growth factor 1 (IGF-1) is considered to be a crucial gene in the animal development of bone and body size. In this study, a unique synonymous mutation (c.258 A > G) of the IGF-1 gene was modified with an adenine base editor to observe the growth and developmental situation of mutant...

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Bibliographic Details
Main Authors: S.Y. Wang, Y.Y. Cheng, S.C. Liu, Y.X. Xu, Y. Gao, C.L. Wang, Z.G. Wang, T.Q. Feng, G.H. Lu, J. Song, P.J. Xia, L.L. Hao
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
base editor
gene-expression process
IGF-1
synonymous codons
growth and development traits
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002018

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http://www.sciencedirect.com/science/article/pii/S2162253121002018

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