Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

The p53 transcription factor is a potent suppressor of tumor growth. We report here an analysis of its direct transcriptional program using Global Run-On sequencing (GRO-seq). Shortly after MDM2 inhibition by Nutlin-3, low levels of p53 rapidly activate ∼200 genes, most of them not previously establ...

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Bibliographic Details
Main Authors: Mary Ann Allen, Zdenek Andrysik, Veronica L Dengler, Hestia S Mellert, Anna Guarnieri, Justin A Freeman, Kelly D Sullivan, Matthew D Galbraith, Xin Luo, W Lee Kraus, Robin D Dowell, Joaquin M Espinosa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
tumor supressor
genomic
p21
PUMA
PIG3
eRNA
Online Access:https://elifesciences.org/articles/02200

Internet

https://elifesciences.org/articles/02200

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