The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis

The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis

Solute carriers are increasingly recognized as participating in a plethora of pathologies, including cancer. We describe here the involvement of the orphan solute carrier Major Facilitator Superfamily Domain-containing protein 1 (MFSD1) in the regulation of tumor cell migration. Loss of MFSD1 enable...

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Bibliographic Details
Main Authors: Marko Roblek, Julia Bicher, Merel van Gogh, Attila György, Rita Seeböck, Bozena Szulc, Markus Damme, Mariusz Olczak, Lubor Borsig, Daria E. Siekhaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Oncology
Subjects:
solute carriers (SLC)
MFSD1
tumor cell migration
integrin recycling
tumor cell metastasis
N-glycan
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.777634/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.777634/full

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