Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells

Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells

Abstract Background Tumor cells express immune-checkpoint molecules to suppress anti-tumor immune responses. In part, immune evasion takes place by secreting exosomes bearing immune-checkpoint and immunomodulatory molecules and their inducing and/or regulating agents e.g., microRNAs (miRs). This stu...

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Bibliographic Details
Main Authors: Sepideh Maralbashi, Cynthia Aslan, Houman Kahroba, Milad Asadi, Mohammad Sadegh Soltani-Zangbar, Navideh Haghnavaz, Farhad Jadidi, Farhad Salari, Tohid Kazemi
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Nutrition
Subjects:
Docosahexaenoic acid
Breast cancer
Exosome
Immune-checkpoints
MicroRNA
Online Access:https://doi.org/10.1186/s40795-024-00844-y

Internet

https://doi.org/10.1186/s40795-024-00844-y

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