Bottom-up synthetic biology approach for improving the efficiency of menaquinone-7 synthesis in Bacillus subtilis

Bottom-up synthetic biology approach for improving the efficiency of menaquinone-7 synthesis in Bacillus subtilis

Abstract Background Menaquinone-7 (MK-7), which is associated with complex and tightly regulated pathways and redox imbalances, is produced at low titres in Bacillus subtilis. Synthetic biology provides a rational engineering principle for the transcriptional optimisation of key enzymes and the arti...

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Bibliographic Details
Main Authors: Xiumin Ding, Zhiming Zheng, Genhai Zhao, Li Wang, Han Wang, Qiang Yang, Mengxue Zhang, Luyao Li, Peng Wang
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Microbial Cell Factories
Subjects:
Menaquinone-7
Bacillus subtilis
Synthetic biology
Metabolic engineering
Cofactor engineering
NADH kinase
Online Access:https://doi.org/10.1186/s12934-022-01823-3

Internet

https://doi.org/10.1186/s12934-022-01823-3

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