Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity

Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity

Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules. Since doxycycline impacts α-synuclein aggregation and tox...

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Bibliographic Details
Main Authors: Luciana Medina, Florencia González-Lizárraga, Antonio Dominguez-Meijide, Diego Ploper, Valeria Parrales, Sabrina Sequeira, Maria-Sol Cima-Omori, Markus Zweckstetter, Elaine Del Bel, Patrick P. Michel, Tiago Fleming Outeiro, Rita Raisman-Vozari, Rosana Chehín, Sergio B. Socias
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
tauopathies
Alzheimer's disease
doxycycline
protein aggregation
tau
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.635760/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.635760/full

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