Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer

Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer

Abstract Background Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis and drug-resistance. Disheveled3 (DVL3) is involved in malignant behaviors of cancer. However, the role and potential mechanism of DVL3 remain elusive in EMT and CS...

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Bibliographic Details
Main Authors: Zhengguang Li, Zhirong Yang, Wei Liu, Wanglong Zhu, Lan Yin, Zhenyu Han, Yu Xian, Jie Wen, Hualong Tang, Xinyue Lin, Yuhan Yang, Jingyi Wang, Kun Zhang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Translational Medicine
Subjects:
Disheveled
Stem cell
Epithelial-to-mesenchymal transition
Colorectal cancer
SOX2
Online Access:https://doi.org/10.1186/s12967-023-04120-8

Internet

https://doi.org/10.1186/s12967-023-04120-8

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