Fisetin, a dietary flavonoid, attenuates hyperammonemia and improves circadian locomotor deficits, redox balance, and astrocytic markers in rats

Fisetin, a dietary flavonoid, attenuates hyperammonemia and improves circadian locomotor deficits, redox balance, and astrocytic markers in rats

Fisetin, a bioactive flavonoid, found in many fruits, was administered orally (50 mg/kg body weight) to hyperammonemic rats (treated with ammonium chloride (AC) for 8 weeks (i.p. injections, 100 mg/kg body weight). Treatment with AC augmented oxidative stress, levels of ammonia, enzymes (alanine and...

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Bibliographic Details
Main Authors: Perumal Subramanian, Murugesan Jayakumar, Muniyandi Singaravel, Dhanananajay Kumar, Priyoneel Basu, Jaime Jacqueline Jayapalan, Onn Haji Hashim
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Functional Foods
Subjects:
Hyperammonemia
Fisetin
Circadian
Redox balance
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464614003752

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http://www.sciencedirect.com/science/article/pii/S1756464614003752

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