Z-REX uncovers a bifurcation in function of Keap1 paralogs

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-à-vis off-target, modifications. By combining bolus dosing, knockdown, and Z-REX—a tool investigating on-target/on-pathway electrophile signaling, we document that electrophile...

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Bibliographic Details
Main Authors: Alexandra Van Hall-Beauvais, Jesse R Poganik, Kuan-Ting Huang, Saba Parvez, Yi Zhao, Hong-Yu Lin, Xuyu Liu, Marcus John Curtis Long, Yimon Aye
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
Keap1/Nrf2 antioxidant response
electrophile signaling
paralog-specific signaling
zebrafish
REX technologies
covalent drug mode-of-action
Online Access:https://elifesciences.org/articles/83373

Internet

https://elifesciences.org/articles/83373

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