Engineering chromosome rearrangements in cancer
The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, delet...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2021-09-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/14/9/dmm049078 |
| _version_ | 1818575429088313344 |
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| author | Salvador Alonso Lukas E. Dow |
| author_facet | Salvador Alonso Lukas E. Dow |
| author_sort | Salvador Alonso |
| collection | DOAJ |
| description | The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, deletions and translocations in model systems. The emergence and refinement of genome editing technologies, such as CRISPR, have significantly expanded our ability to generate and interrogate chromosomal aberrations to better understand the networks that govern cancer growth. Here we review how existing technologies are employed to faithfully model cancer-associated chromosome rearrangements in the laboratory, with the ultimate goal of developing more accurate pre-clinical models of and therapeutic strategies for cancers driven by these genomic events. |
| first_indexed | 2024-12-15T00:40:10Z |
| format | Article |
| id | doaj.art-eda448234cfe4f4da8c0d419f9cf9553 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-12-15T00:40:10Z |
| publishDate | 2021-09-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-eda448234cfe4f4da8c0d419f9cf95532022-12-21T22:41:41ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112021-09-0114910.1242/dmm.049078049078Engineering chromosome rearrangements in cancerSalvador Alonso0Lukas E. Dow1 Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, deletions and translocations in model systems. The emergence and refinement of genome editing technologies, such as CRISPR, have significantly expanded our ability to generate and interrogate chromosomal aberrations to better understand the networks that govern cancer growth. Here we review how existing technologies are employed to faithfully model cancer-associated chromosome rearrangements in the laboratory, with the ultimate goal of developing more accurate pre-clinical models of and therapeutic strategies for cancers driven by these genomic events.http://dmm.biologists.org/content/14/9/dmm049078crisprcancerchromosomal rearrangementsfusion oncogenes |
| spellingShingle | Salvador Alonso Lukas E. Dow Engineering chromosome rearrangements in cancer Disease Models & Mechanisms crispr cancer chromosomal rearrangements fusion oncogenes |
| title | Engineering chromosome rearrangements in cancer |
| title_full | Engineering chromosome rearrangements in cancer |
| title_fullStr | Engineering chromosome rearrangements in cancer |
| title_full_unstemmed | Engineering chromosome rearrangements in cancer |
| title_short | Engineering chromosome rearrangements in cancer |
| title_sort | engineering chromosome rearrangements in cancer |
| topic | crispr cancer chromosomal rearrangements fusion oncogenes |
| url | http://dmm.biologists.org/content/14/9/dmm049078 |
| work_keys_str_mv | AT salvadoralonso engineeringchromosomerearrangementsincancer AT lukasedow engineeringchromosomerearrangementsincancer |