Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells

Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells

Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by endothelial cells (ECs) from human eye choroid. We demonstrate that retinal pigment epithelium (RPE)-conditioned medium induces A2M expression...

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Bibliographic Details
Main Authors: Guillermo L. Lehmann, Michael Ginsberg, Daniel J. Nolan, Cristina Rodríguez, José Martínez-González, Shemin Zeng, Andrew P. Voigt, Robert F. Mullins, Shahin Rafii, Enrique Rodriguez-Boulan, Ignacio Benedicto
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
Alpha-2-macroglobulin (A2M)
retinal pigment epithelium (RPE)
vascular endothelial growth factor-A (VEGF-A)
endothelial cells (ECs)
extracellular matrix (ECM)
matrix metalloproteinase-2 (MMP-2)
Online Access:https://www.mdpi.com/2073-4409/11/19/2975

Internet

https://www.mdpi.com/2073-4409/11/19/2975

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