Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1–HIF1α‐mediated glycolysis–OXPHOS metabolism shift

Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1–HIF1α‐mediated glycolysis–OXPHOS metabolism shift

Abstract Introduction Developmental dysplasia of hip (DDH) is a hip joint disorder leading to subsequent osteoarthritis. Previous studies suggested collagen XI alpha 1 (COL11A1) as a potential gene in hip dysplasia and chondrocyte degeneration. However, no genetic association has reported COL11A1‐re...

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Bibliographic Details
Main Authors: Ye Sun, Yongqing You, Qiang Wu, Rui Hu, Kerong Dai
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Clinical and Translational Medicine
Subjects:
cellular senescence
genetics
glycolysis
hip dysplasia
organoids
osteoarthritis
Online Access:https://doi.org/10.1002/ctm2.1574

Internet

https://doi.org/10.1002/ctm2.1574

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