Translational modulator ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Translational modulator ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Summary: Fragile X syndrome (FXS) is caused by the loss of fragile X messenger ribonucleoprotein (FMRP), a translational regulator that binds the transcripts of proteins involved in synaptic function and plasticity. Dysregulated protein synthesis is a central effect of FMRP loss, however, direct tra...

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Bibliographic Details
Main Authors: Rochelle L. Coulson, Valentina Frattini, Caitlin E. Moyer, Jennifer Hodges, Peter Walter, Philippe Mourrain, Yi Zuo, Gordon X. Wang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Small molecule
Molecular neuroscience
Cellular neuroscience
Cell biology
Model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224004802

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http://www.sciencedirect.com/science/article/pii/S2589004224004802

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