Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters

Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters

In this study, we delve into the impact of genotoxic anticancer drug treatment on the chromatin structure of human cells, with a particular focus on the effects of doxorubicin. Using Hi-C, ChIP-seq, and RNA-seq, we explore the changes in chromatin architecture brought about by doxorubicin and ICRF19...

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Bibliographic Details
Main Authors: Maria E. Stefanova, Elizabeth Ing-Simmons, Stefan Stefanov, Ilya Flyamer, Heathcliff Dorado Garcia, Robert Schöpflin, Anton G. Henssen, Juan M. Vaquerizas, Stefan Mundlos
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
Hi-C
Top2
doxorubicin
chemotherapy
DSBs
promoters
Online Access:https://www.mdpi.com/2073-4409/12/15/2001

Internet

https://www.mdpi.com/2073-4409/12/15/2001

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