Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches

Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches

Heat shock protein 27 (HSP27) is a protein that works as a chaperone and an antioxidant and is activated by heat shock, environmental stress, and pathophysiological stress. However, HSP27 dysregulation is a characteristic of many human cancers. HSP27 suppresses apoptosis and cytoskeletal reorganizat...

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Bibliographic Details
Main Authors: Haruna Isiyaku Umar, Adeola Temitayo Ajayi, Nobendu Mukerjee, Abdullahi Tunde Aborode, Mohammad Mehedi Hasan, Swastika Maitra, Ridwan O. Bello, Hafsat O. Alabere, Afees A. Sanusi, Olamide O. Awolaja, Mohammed M. Alshehri, Prosper O. Chukwuemeka, Nada H. Aljarba, Saad Alkahtani, Sumira Malik, Athanasios Alexiou, Arabinda Ghosh, Md. Habibur Rahman
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
HSP27 inhibitor
anti-cancer resistance
computer-assisted therapeutic discovery
anti-cancer agent
cancer therapy
molecular docking
Online Access:https://www.mdpi.com/2073-4409/11/15/2412

Internet

https://www.mdpi.com/2073-4409/11/15/2412

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