One-Pot and Catalyst-Free Transformation of <i>N</i>-Protected 1-Amino-1-Ethoxyalkylphosphonates into Bisphosphonic Analogs of Protein and Non-Protein α-Amino Acids

One-Pot and Catalyst-Free Transformation of <i>N</i>-Protected 1-Amino-1-Ethoxyalkylphosphonates into Bisphosphonic Analogs of Protein and Non-Protein α-Amino Acids

Herein, we describe the development of one-pot transformation of α-ethoxy derivatives of phosphorus analogs of protein and non-protein α-amino acids into biologically important <i>N</i>-protected 1-aminobisphosphonates. The proposed strategy, based on the three-component reaction of 1-(&...

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Bibliographic Details
Main Authors: Anna Kuźnik, Dominika Kozicka, Wioleta Hawranek, Karolina Socha, Karol Erfurt
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
α-aminobisphosphonates
α-ethoxyphosphonates
phosphonium salts
<i>N</i>-acylimidates
Michaelis–Becker reaction
Michaelis–Arbuzov reaction
Online Access:https://www.mdpi.com/1420-3049/27/11/3571

Internet

https://www.mdpi.com/1420-3049/27/11/3571

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