Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1)

Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1)

Abstract Background The potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear. This study aims to explore the epigenetic dysregulation mechanism of miRNA-493 and the ability to modulate lung cancer cell chemotherapy r...

Full description

Bibliographic Details
Main Authors: Yixue Gu, Zhijie Zhang, Jiang Yin, Jiahui Ye, Yin Song, Hao Liu, Yan Xiong, Minying Lu, Guopei Zheng, Zhimin He
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lung cancer
Cisplatin miR-493
TCRP1
Online Access:http://link.springer.com/article/10.1186/s13046-017-0582-5

Internet

http://link.springer.com/article/10.1186/s13046-017-0582-5

Similar Items