Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury

Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury

Summary: Synaptic inhibition is critical for controlling neuronal excitability and function. During global cerebral ischemia (GCI), inhibitory synapses are rapidly eliminated, causing hyper-excitability which contributes to cell-death and the pathophysiology of disease. Sequential disassembly of inh...

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Bibliographic Details
Main Authors: Joshua D. Garcia, Sarah E. Wolfe, Amber R. Stewart, Erika Tiemeier, Sara E. Gookin, Mayra Bueno Guerrero, Nidia Quillinan, Katharine R. Smith
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Cellular neuroscience
Molecular physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223021387

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http://www.sciencedirect.com/science/article/pii/S2589004223021387

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