Involvement of Mitochondrial Mechanisms in the Cytostatic Effect of Desethylamiodarone in B16F10 Melanoma Cells

Involvement of Mitochondrial Mechanisms in the Cytostatic Effect of Desethylamiodarone in B16F10 Melanoma Cells

Previously, we showed that desethylamiodarone (DEA), a major metabolite of the widely used antiarrhythmic drug amiodarone, has direct mitochondrial effects. We hypothesized that these effects account for its observed cytotoxic properties and ability to limit in vivo metastasis. Accordingly, we exami...

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Bibliographic Details
Main Authors: Fadi H. J. Ramadan, Aliz Szabo, Dominika Kovacs, Aniko Takatsy, Rita Bognar, Ferenc Gallyas, Zita Bognar
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
amiodarone
apoptosis
metastatic melanoma
mitochondrial fusion-fission
mPT
Bad
Online Access:https://www.mdpi.com/1422-0067/21/19/7346

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https://www.mdpi.com/1422-0067/21/19/7346

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