Down regulating PHGDH affects the lactate production of sertoli cells in varicocele

Down regulating PHGDH affects the lactate production of sertoli cells in varicocele

Abstract Background Although varicocele is considered to be one of the leading causes of male infertility, the precise mechanism underlying how varicocele leads to male infertility is not completely understood. We found the lactate concentration on the varicocele side of the patients was decreased c...

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Bibliographic Details
Main Authors: Wen-bin Guo, Zhen-hui Huang, Cheng Yang, Xian-yuan Lv, Hui Xia, Hu Tian, Jian-kun Yang, Qi-zhao Zhou, Ming-kun Chen, Kang-yi Xue, Cun-dong Liu
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
Varicocele
Phosphoglycerate dehydrogenase (PHGDH)
Glycolysis
Lactate metabolism
Sertoli cells (SC)
Online Access:http://link.springer.com/article/10.1186/s12958-020-00625-9

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http://link.springer.com/article/10.1186/s12958-020-00625-9

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