Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

ABSTRACT Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics. In response to this significant clinical t...

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Bibliographic Details
Main Authors: Melissa D. Barnes, Magdalena A. Taracila, Joseph D. Rutter, Christopher R. Bethel, Ioannis Galdadas, Andrea M. Hujer, Emilia Caselli, Fabio Prati, John P. Dekker, Krisztina M. Papp-Wallace, Shozeb Haider, Robert A. Bonomo
Format: Article
Language:English
Published: American Society for Microbiology 2018-12-01
Series:mBio
Subjects:
AmpC
PDC-3
antibiotic resistance
beta-lactam
beta-lactamase
ceftolozane
Online Access:https://journals.asm.org/doi/10.1128/mBio.02085-18

Internet

https://journals.asm.org/doi/10.1128/mBio.02085-18

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