Nesfatin-1 in the Lateral Parabrachial Nucleus Inhibits Food Intake, Modulates Excitability of Glucosensing Neurons, and Enhances UCP1 Expression in Brown Adipose Tissue

Nesfatin-1 in the Lateral Parabrachial Nucleus Inhibits Food Intake, Modulates Excitability of Glucosensing Neurons, and Enhances UCP1 Expression in Brown Adipose Tissue

Nesfatin-1, an 82-amino acid neuropeptide, has been shown to induce anorexia and energy expenditure. Food intake is decreased in ad libitum-fed rats following injections of nesfatin-1 into the lateral, third, or fourth ventricles of the brain. Although the lateral parabrachial nucleus (LPBN) is a ke...

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Bibliographic Details
Main Authors: Jing Dong, Jun-hua Yuan, Xi Chen, Di Zhang, Kun Song, Yue Zhang, Guang-bo Wu, Xi-hao Hu, Zheng-yao Jiang, Peng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Physiology
Subjects:
food intake
energy expenditure
glucose sensitive neurons
lateral parabrachial nucleus
nesfatin-1
SHU9119
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00235/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00235/full

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