Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells

Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells

Abstract Background Glioblastoma (GBM) is an immunosuppressive, highly vascular and devastating malignant brain tumor. Even with progressive combination treatment that includes surgery, radiotherapy, and chemotherapy, the prognosis for GBM patients is still extremely poor. Oncolytic adenovirus (OAd)...

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Bibliographic Details
Main Authors: Qing Zhang, Junwen Zhang, Yifu Tian, Guidong Zhu, Sisi Liu, Fusheng Liu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cell & Bioscience
Subjects:
Glioblastoma
Oncolytic adenovirus
Ki-67 promoter
IL-15
Immunotherapy
Angiogenesis
Online Access:http://link.springer.com/article/10.1186/s13578-020-00485-1

Internet

http://link.springer.com/article/10.1186/s13578-020-00485-1

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