Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model

Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model

Abstract Background Patients with critical limb ischemia (CLI) are at great risk of major amputation and cardiovascular events. Adipose-derived mesenchymal stem cell (ADSC) therapy is a promising therapeutic strategy for CLI, but the poor engraftment and insufficient angiogenic ability of ADSCs limi...

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Bibliographic Details
Main Authors: Zekun Shen, Weiyi Wang, Jinxing Chen, Bingyi Chen, Yanan Tang, Jiaxuan Hou, Jiayan Li, Shuang Liu, Yifan Mei, Liwei Zhang, Shaoying Lu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Nanobiotechnology
Online Access:https://doi.org/10.1186/s12951-022-01632-1

Internet

https://doi.org/10.1186/s12951-022-01632-1

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