Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress

Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress

Abstract The chronic inflammatory process that characterizes inflammatory bowel diseases (IBD) is mainly driven by T-cell response to microbial and environmental antigens. Psychological stress is a potential trigger of clinical flares of IBD, and sphingosine-1-phosphate (S1P) is involved in T-cell r...

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Bibliographic Details
Main Authors: David Martín-Hernández, Irene L. Gutiérrez, Marta González-Prieto, Karina S. MacDowell, Javier Robledo-Montaña, Hiram Tendilla-Beltrán, Natalia Calleja-Rodríguez, Álvaro G. Bris, Cristina Ulecia-Morón, Beatriz Moreno, Javier R. Caso, Borja García-Bueno, Sandra Rodrigues-Mascarenhas, Ignacio Marín-Jiménez, Juan Carlos Leza, Luis Menchén
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-08011-8

Internet

https://doi.org/10.1038/s41598-022-08011-8

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