THYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISMS AND SUSCEPTIBILITY TO ESOPHAGEAL CANCER: A CASE-CONTROL STUDY

THYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISMS AND SUSCEPTIBILITY TO ESOPHAGEAL CANCER: A CASE-CONTROL STUDY

ABSTRACT BACKGROUND: The enzyme methylenetetrahydrofolate reductase is engaged in DNA synthesis through folate metabolism. Inhibiting the activity of this enzyme increases the susceptibility to mutations, and damage and aberrant DNA methylation, which alters the gene expression of tumor suppressors...

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Bibliographic Details
Main Authors: Evelise Pelegrinelli Zaidan, Michele Tatiana Pereira Tomitão, Marina Alessandra Pereira, Marcia Saldanha Kubrusly, Adriana Vaz Safatle-Ribeiro, Flavio Roberto Takeda, Ivan Cecconello, Ulysses Ribeiro Junior
Format: Article
Language:English
Published: Colégio Brasileiro de Cirurgia Digestiva 2022-09-01
Series:ABCD: Arquivos Brasileiros de Cirurgia Digestiva
Subjects:
Esophageal Neoplasms
Adenocarcinoma
Carcinoma, Squamous Cell
Polymorphism, Genetic
Methylenetetrahydrofolate Reductase (NADPH2)
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202022000100330&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202022000100330&tlng=en

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