Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of <i>Trypanosoma brucei rhodesiense</i>

Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of <i>Trypanosoma brucei rhodesiense</i>

Rhodesain is a cysteine protease that is crucial for the life cycle of <i>Trypanosoma brucei rhodesiense</i>, a parasite causing the lethal form of Human African Trypanosomiasis. <b>CD24</b> is a recently developed synthetic inhibitor of rhodesain, characterized by a nanomola...

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Bibliographic Details
Main Authors: Carla Di Chio, Santo Previti, Fabiola De Luca, Marta Bogacz, Collin Zimmer, Annika Wagner, Tanja Schirmeister, Maria Zappalà, Roberta Ettari
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
cysteine protease
rhodesain inhibitors
dipeptide nitrile
curcumin
combination studies
Online Access:https://www.mdpi.com/1422-0067/23/22/14470

Internet

https://www.mdpi.com/1422-0067/23/22/14470

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