Acidic Growth Conditions Promote Epithelial-to-Mesenchymal Transition to Select More Aggressive PDAC Cell Phenotypes In Vitro

Acidic Growth Conditions Promote Epithelial-to-Mesenchymal Transition to Select More Aggressive PDAC Cell Phenotypes In Vitro

Pancreatic Ductal Adenocarcinoma (PDAC) is characterized by an acidic microenvironment, which contributes to therapeutic failure. So far there is a lack of knowledge with respect to the role of the acidic microenvironment in the invasive process. This work aimed to study the phenotypic and genetic r...

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Bibliographic Details
Main Authors: Madelaine Magalì Audero, Tiago Miguel Amaral Carvalho, Federico Alessandro Ruffinatti, Thorsten Loeck, Maya Yassine, Giorgia Chinigò, Antoine Folcher, Valerio Farfariello, Samuele Amadori, Chiara Vaghi, Albrecht Schwab, Stephan J. Reshkin, Rosa Angela Cardone, Natalia Prevarskaya, Alessandra Fiorio Pla
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cancers
Subjects:
acidic tumor microenvironment
acid-selection
PDAC
cell proliferation
cell adhesion
cell migration
Online Access:https://www.mdpi.com/2072-6694/15/9/2572

Internet

https://www.mdpi.com/2072-6694/15/9/2572

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