USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication

USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication

The antiviral activity of host factor apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G, A3G) and its degradation mediated by human immunodeficiency virus type 1 (HIV-1) Vif protein are important topics. Although accumulating evidence indicates the importance of deubiquiti...

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Bibliographic Details
Main Authors: Ting Pan, Zheng Song, Liyang Wu, Guangyan Liu, Xiancai Ma, Zhilin Peng, Mo Zhou, Liting Liang, Bingfeng Liu, Jun Liu, Junsong Zhang, Xuanhong Zhang, Ryan Huang, Jiacong Zhao, Yonghong Li, Xuemei Ling, Yuewen Luo, Xiaoping Tang, Weiping Cai, Kai Deng, Linghua Li, Hui Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
USP49
HIV-1
APOBEC3G
Vif
deubiquitination
Online Access:https://elifesciences.org/articles/48318

Internet

https://elifesciences.org/articles/48318

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