Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics

Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics

Myoglobin (Mb)-mediated oxygen (O<sub>2</sub>) delivery and dissolved O<sub>2</sub> in the cytosol are two major sources that support oxidative phosphorylation. During intense exercise, lactate (LAC) production is elevated in skeletal muscles as a consequence of insufficient...

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Bibliographic Details
Main Authors: Kiran Kumar Adepu, Dipendra Bhandari, Andriy Anishkin, Sean H. Adams, Sree V. Chintapalli
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
binding
lactate
lactic acidosis
myoglobin
oxygen release
Online Access:https://www.mdpi.com/1422-0067/23/9/4747

Internet

https://www.mdpi.com/1422-0067/23/9/4747

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