High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

Abstract Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to stabilize its prefusion conformation. However, contemporary methods on engineering prefusion-stabilized spike im...

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Bibliographic Details
Main Authors: Timothy J. C. Tan, Zongjun Mou, Ruipeng Lei, Wenhao O. Ouyang, Meng Yuan, Ge Song, Raiees Andrabi, Ian A. Wilson, Collin Kieffer, Xinghong Dai, Kenneth A. Matreyek, Nicholas C. Wu
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37786-1

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https://doi.org/10.1038/s41467-023-37786-1

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