Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity

Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity

Mycobacterium abscessus (Mab) is a rapidly growing non-tuberculous mycobacterium (NTM) that causes a wide range of infections. Treatment of Mab infections is difficult because the bacterium is intrinsically resistant to many classes of antibiotics. Developing new and effective treatments against Mab...

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Bibliographic Details
Main Authors: Chidiebere Akusobi, Bouchra S Benghomari, Junhao Zhu, Ian D Wolf, Shreya Singhvi, Charles L Dulberger, Thomas R Ioerger, Eric J Rubin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
Mycobacterium abscessus
peptidoglycan
cell wall
transposon sequencing (TnSeq)
PBP
antibiotic sensitivity
Online Access:https://elifesciences.org/articles/71947

Internet

https://elifesciences.org/articles/71947

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