Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species.

Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species.

Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation product of the viral PB1 segment that was initially characterized as a pro-apoptotic mitocho...

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Bibliographic Details
Main Authors: Mirco Schmolke, Balaji Manicassamy, Lindomar Pena, Troy Sutton, Rong Hai, Zsuzsanna T Varga, Benjamin G Hale, John Steel, Daniel R Pérez, Adolfo García-Sastre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3154844?pdf=render

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http://europepmc.org/articles/PMC3154844?pdf=render

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