Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

FXR plays an important role in bile acid homeostasis by transcriptionally modulating several enterohepatic genes, including intestinal FGF19, that repress hepatic bile acid synthesis. Here the authors show that postprandial FGF19 regulates FXR transcriptional activity via its action on the tyrosine...

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Bibliographic Details
Main Authors: Sangwon Byun, Dong-Hyun Kim, Daniel Ryerson, Young-Chae Kim, Hao Sun, Bo Kong, Peter Yau, Grace Guo, H. Eric Xu, Byron Kemper, Jongsook Kim Kemper
Format: Article
Language:English
Published: Nature Portfolio 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04697-5

Internet

https://doi.org/10.1038/s41467-018-04697-5

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