Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

Summary: Human induced pluripotent stem cells (hiPSCs) show variable differentiation potential due to their epigenomic heterogeneity, whose extent/attributes remain unclear, except for well-studied elements/chromosomes such as imprints and the X chromosomes. Here, we show that seven hiPSC lines with...

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Bibliographic Details
Main Authors: Shihori Yokobayashi, Yukihiro Yabuta, Masato Nakagawa, Keisuke Okita, Bo Hu, Yusuke Murase, Tomonori Nakamura, Guillaume Bourque, Jacek Majewski, Takuya Yamamoto, Mitinori Saitou
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
human induced pluripotent stem cells
clonal heterogeneity
epigenome
histone modifications
DNA methylation
X chromosome inactivation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013826

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http://www.sciencedirect.com/science/article/pii/S2211124721013826

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