The impact of ABCB1, CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation

The impact of ABCB1, CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation

Abstract Background The influence of genetic factors on the pharmacokinetics and clinical outcomes of rivaroxaban in patients with non-valvular atrial fibrillation (NVAF) is poorly understood. This study aimed to explore the effects of CYP3A4/5, ABCB1, and ABCG2 gene polymorphisms on the trough conc...

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Bibliographic Details
Main Authors: Tingting Wu, Shuyi Wu, Li Li, Jing Xiang, Na Wang, Wenjun Chen, Jinhua Zhang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Human Genomics
Subjects:
Rivaroxaban
Gene polymorphisms
Pharmacokinetics
Bleeding
Non-valvular atrial fibrillation
Online Access:https://doi.org/10.1186/s40246-023-00506-3

Internet

https://doi.org/10.1186/s40246-023-00506-3

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