Microarrayed human bone marrow organoids for modeling blood stem cell dynamics

Microarrayed human bone marrow organoids for modeling blood stem cell dynamics

In many leukemia patients, a poor prognosis is attributed either to the development of chemotherapy resistance by leukemic stem cells (LSCs) or to the inefficient engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs) into the bone marrow (BM). Here, we build a 3D in vitro model sys...

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Bibliographic Details
Main Authors: Sonja Giger, Moritz Hofer, Marijana Miljkovic-Licina, Sylke Hoehnel, Nathalie Brandenberg, Romain Guiet, Martin Ehrbar, Esther Kleiner, Katharina Gegenschatz-Schmid, Thomas Matthes, Matthias P. Lutolf
Format: Article
Language:English
Published: AIP Publishing LLC 2022-09-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/5.0092860

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http://dx.doi.org/10.1063/5.0092860

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