Knockdown of LMNB1 Inhibits the Proliferation of Lung Adenocarcinoma Cells by Inducing DNA Damage and Cell Senescence

Knockdown of LMNB1 Inhibits the Proliferation of Lung Adenocarcinoma Cells by Inducing DNA Damage and Cell Senescence

BackgroundLung cancer has considerably high mortality and morbidity rate. Lung adenocarcinoma (LUAD) tissues highly express lamin B1 (LMNB1), compared with normal tissues. In this study, we knocked down LMNB1 in LUAD cells A549 and NCI-1299 to explore the effect of its inhibition on the proliferatio...

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Bibliographic Details
Main Authors: Jiangbo Li, Zhijia Sun, Yingshu Cui, Lingmei Qin, Fengyun Wu, Yufang Li, Nan Du, Xiaosong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
LMNB1
LUAD
chromosome accessibility
telomere
cell senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.913740/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.913740/full

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