Generation and characterization of antagonistic anti-human CD39 nanobodies

Generation and characterization of antagonistic anti-human CD39 nanobodies

CD39 is the major enzyme controlling the levels of extracellular adenosine triphosphate (ATP) via the stepwise hydrolysis of ATP to adenosine diphosphate (ADP) and adenosine monophosphate (AMP). As extracellular ATP is a strong promoter of inflammation, monoclonal antibodies (mAbs) blocking CD39 are...

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Bibliographic Details
Main Authors: Stephan Menzel, Yinghui Duan, Julia Hambach, Birte Albrecht, Dorte Wendt-Cousin, Riekje Winzer, Eva Tolosa, Anne Rissiek, Andreas H. Guse, Friedrich Haag, Tim Magnus, Friedrich Koch-Nolte, Björn Rissiek
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
nanobody
CD39
ENTPD1
VHH
single-domain antibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1328306/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1328306/full

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