SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage

SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage

ABSTRACT The recent emergence of the omicron variant of the SARS-CoV-2 virus with large numbers of mutations has raised concern about a potential new surge in infections. Here we use molecular dynamics to study the biophysics of the interface of the BA1 and BA2 omicron spike protein binding to (i) t...

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Bibliographic Details
Main Authors: M. Zaki Jawaid, A. Baidya, R. Mahboubi-Ardakani, Richard L. Davis, Daniel L. Cox
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
omicron
spike
ACE2
furin
antibody escape
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01213-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01213-22

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