Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD

Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD

Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders on a disease spectrum that are characterized by the cytoplasmic mislocalization and aberrant phase transitions of prion-like RNA-binding proteins (RBPs). The common accumulation of TA...

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Detalles Bibliográficos
Main Authors: Bilal Khalil, Miriam Linsenmeier, Courtney L. Smith, James Shorter, Wilfried Rossoll
Formato: Artigo
Idioma:English
Publicado: BMC 2024-01-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
Frontotemporal dementia
FUS
TDP-43
Protein aggregation
Nucleocytoplasmic transport
Acceso en liña:https://doi.org/10.1186/s13024-023-00698-1

Internet

https://doi.org/10.1186/s13024-023-00698-1

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