Characterizing microRNA-mediated modulation of gene expression noise and its effect on synthetic gene circuits

Summary: MicroRNAs (miRNAs) have been shown to modulate gene expression noise, but less is known about how miRNAs with different properties may regulate noise differently. Here, we investigate the role of competing RNAs and the composition of miRNA response elements (MREs) in modulating noise. We fi...

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Bibliographic Details
Main Authors: Lei Wei, Shuailin Li, Pengcheng Zhang, Tao Hu, Michael Q. Zhang, Zhen Xie, Xiaowo Wang
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472101007X