Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer’s Disease

Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer’s Disease

In this study, we aimed to disclose the impact of amyloid-β toxicity and tau pathology on astrocyte swelling, their volume recovery and extracellular space (ECS) diffusion parameters, namely volume fraction (α) and tortuosity (λ), in a triple transgenic mouse model of Alzheimer’s disease (3xTg-AD)....

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Bibliographic Details
Main Authors: Jana Tureckova, Monika Kamenicka, Denisa Kolenicova, Tereza Filipi, Zuzana Hermanova, Jan Kriska, Lenka Meszarosova, Barbora Pukajova, Lukas Valihrach, Peter Androvic, Daniel Zucha, Martina Chmelova, Lydia Vargova, Miroslava Anderova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
astrocytes
ECS diffusion
volume changes
astrocyte heterogeneity
ion uptake
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.783120/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.783120/full

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